Pharmacokinetics: A Comprehensive Overview of Principles and Applications

Course Description

The course will provide participants with a comprehensive overview of pharmacokinetics by integrating concepts in physiology and mathematics. At the end of this seminar, attendees will understand fundamental pharmacokinetic concepts and be able to use them to design pharmacokinetic studies, compute pharmacokinetic parameters, and predict the effect of physiological and formulation changes on the pharmacokinetics of drugs. The instructor will provide an overview of the anatomy and physiology of organ systems relevant to drug absorption, distribution, metabolism, and excretion, explain pharmacokinetic concepts, demonstrate computation of pharmacokinetic parameters after intravenous and/oral doses, and highlight concepts in bioavailability, bioequivalence, and biopharmaceutics. Understanding of theoretical principles will be facilitated by numerous practical examples from the literature, and through case studies. Periodic review and reinforcement of important concepts will be achieved through discussions, and completion of a series of in-class assignments.

Learning Objectives

• Describe the anatomy and physiology of systems involved in drug absorption, distribution, and elimination
• Compute pharmacokinetic parameters after intravenous and/oral drug administration
• Design pharmacokinetic studies
• Analyze and interpret data from pharmacokinetic studies
• Evaluate bioequivalence data
• Predict the effect of physiological and formulation changes on the pharmacokinetics of drugs

Who Should Attend

• This course is designed for individuals working in the pharmaceutical industry with degrees in biology, chemistry, or chemical engineering who desire an understanding of the fundamental principles and concepts in pharmacokinetics

Instructor

The course will be led by one of the following instructors:

Anil D’Mello, Ph.D.

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Course Outline

Day One: 8:30 a.m. – 4:30 p.m.

• Anatomy and Physiology: Anatomy and physiology of systems responsible for drug absorption, distribution, metabolism, and excretion
• Intravenous Dose: Conceptual description and computation of half-life, volume of distribution, area under the plasma concentration – time curve, and clearance
• Oral Absorption: Description of the phases in drug absorption, computation of halflife, volume of distribution, area under the plasma concentration – time curve, clearance, Cmax, and tmax; effect of alterations in pharmacokinetic parameters on the area under the plasma concentration – time curve, Cmax, and tmax of the drug

Day Two: 8:30 a.m. – 4:30 p.m.

• Bioavailability and Bioequivalence: Definition of terms and computation of bioavailability and bioequivalence; design of bioavailability studies; historical perspective of statistical techniques used to evaluate bioequivalence data
• Physiological and Formulation Factors Affecting Drug Absorption: Effect of food, drug solubility, permeability, and surface area on the rate and extent of drug absorption
• Clearance Concepts: Physiological model for organ clearance and the effect of alterations in organ blood flow, intrinsic clearance, and plasma protein binding on drug pharmacokinetics

Interactive Activities

• Classroom discussions customized to participants’ backgrounds and questions
• A series of in-class assignments
• Group examination of case studies

Registration Fees

Registration fees include assorted breakfast items that will be available each day ½ hour prior to the start of the seminar. Also included is a Networking Lunch that will be served each training day.

Special rates are available for multiple attendees from the same organization.  Contact Melissa Dolen at 781-972-5418 to discuss your options and take advantage of the savings.     

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Accreditation Information

Barnett International is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.  Participants will receive 15 hours (1.5 CEUs) of continuing education credit for full participation, including the completion of a pre-test, post-test, and program evaluation.  Barnett International will issue a receipt of completion for earned CEUs within three weeks of program completion.  ACPE#: 0778-0000-16-036-L01-P. Released: 10/16.

Hold this course at your company! For more information, contact Naila Ganatra at +1 215.413.2471.